Dermalogica Phyto Nature E² Regenerating Daily Exosome Leave-On Treatment 100ml is an advanced leave-on skin renewal treatment designed to support visible regeneration while gently resurfacing dull, aging skin. Formulated with next-generation plant-based exosomes and exfoliating enzymes, this lightweight, silky treatment helps improve the appearance of fine lines, wrinkles, dullness, uneven texture, loss of firmness and visible signs of premature aging.
The formula combines two complementary approaches to skin renewal: enzymatic resurfacing and exosome-supported regeneration. Exfoliating enzymes help remove dull surface cells, while a regenerative exosome blend supports communication and renewal within multiple layers of the skin’s surface. Together, these technologies help skin appear smoother, brighter and more refined with consistent use.
Unlike a traditional rinse-off exfoliant, Phyto Nature E² is a daily leave-on treatment. Its lightweight texture absorbs quickly and can be layered underneath serums and moisturizers, making it easy to integrate into both morning and evening routines.
Key Ingredients
Regenerative Exosome Blend
A next-generation plant-based exosome complex that acts across multiple layers of the skin’s surface. Dermalogica states that this blend helps support natural regeneration while visibly diminishing the appearance of fine lines and wrinkles.
Pumpkin Enzyme
Provides gentle enzymatic exfoliation by helping clear away dull surface cells, revealing smoother and brighter-looking skin without the need for physical scrubbing.
Phyto Glycogen + Prickly Pear Botanical Blend
Helps visibly brighten and smooth skin, supporting a more refined and radiant complexion.
Bio-Fermented Acetyl Glucosamine
Provides hydration and antioxidant support, helping the skin remain comfortable and conditioned while undergoing regular resurfacing.
The complete formulation also includes Lactic Acid, Glycerin, Hydrolyzed Prickly Pear Flower Extract, Sunflower Seed Oil, Camellia Japonica Flower Extract, Glycogen and additional botanical extracts.
Key Benefits
Supports natural skin regeneration
In laboratory in-vitro testing, Dermalogica reported up to an 86% improvement in natural skin regeneration compared with untreated skin. This figure refers to laboratory testing rather than guaranteed individual consumer results.
Visibly reduces fine lines and wrinkles
In an independent clinical study involving 32 subjects using the treatment twice daily, visible signs of fine lines and wrinkles were reduced in as little as two weeks.
Daily resurfacing for smoother texture
Pumpkin Enzyme helps remove dull surface buildup, supporting smoother and more refined-looking skin.
Brightens dull-looking skin
Regular exfoliation combined with botanical actives helps restore a fresher, more radiant appearance.
Refines uneven texture
Ideal for skin that feels rough, looks fatigued or shows visible signs of slowed renewal associated with aging.
Recommended For
Dermalogica Phyto Nature E² is recommended for:
mature or prematurely aging skin, fine lines and wrinkles, visible loss of firmness and elasticity, dull-looking skin and uneven texture.
How to Use
Apply to clean skin and allow the formula to absorb. Follow with the rest of your skincare routine, such as serum and moisturizer. Dermalogica recommends using the product twice daily. During daytime use, pairing the routine with broad-spectrum sunscreen is advisable when incorporating regular resurfacing products.
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Its combination of plant-based exosomes, Pumpkin Enzyme, Phyto Glycogen, Prickly Pear and Bio-Fermented Acetyl Glucosamine makes it a comprehensive daily treatment for visible renewal, smoother texture, brightness and age-supporting skincare.
